Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly?

A prospective study of patients with communicating hydrocephalus.

In communicating hydrocephalus the cerebral ventricles enlarge despite the absence of any detectable cerebrospinal fluid obstructions. In this prospective study we utilized MRI and computational fluid dynamics to investigate whether pressure differences across the open cerebral aqueduct could explain the ventriculomegaly in these patients, as the aqueduct connects the third and lateral ventricles with the subarachnoid space surrounding the brain. Our research group has extensive experience working with various neurological diseases such as hydrocephalus, with a large amount of publications utilizing MRI and cerebrospinal fluid dynamics investigations.

Ref: Holmlund P, Qvarlander S, Malm J, Eklund A. Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus. Fluids and Barriers of the CNS. 2019;16:40.

 

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